Tennessee (16-3, 7-0) held off Vanderbilt (13-6, 3-3) and claimed sole possession of first place in the SEC after Kentucky lost at South Carolina.
Taber Spani and Meighan Simmons led the way for the Lady Vols with 24 and 23 points, respectively, while logging 37 and 38 minutes of play, respectively.
Both players spoke after the game about the importance of the win over the in-state rival, especially after an embarrassing loss in Nashville a year ago.
Freshman Bashaara Graves also reached double figures with 16 points, and sophomore Isabelle Harrison chipped in with eight points and nine boards.
Christina Foggie led Vandy with 22 points, while Tiffany Clarke added 19, and Kady Schrann tallied 14 points.
Tennessee will next face Notre Dame on Monday in a game being billed as an "Orange Out" for fans. A banner honoring Pat Summitt will be raised before the game.